Heritage Auctions says more than 60,000 tickets to the game at Yankee Stadium were sold. Only two are known to have survived.
[caption id="attachment_46027" align="alignright" width="300"] In this July 4, 1939, file photo, New York Yankees' Lou Gehrig wipes away a tear while speaking during a tribute at Yankee Stadium in New York. Gehrig passed away on June 2, 1941 at the age of 37. (AP Photo/Murray Becker, File)[/caption]
Of the two, only the mezzanine box ticket was signed by Gehrig. It's estimated to bring over $100,000 at the Aug. 1 sale in Cleveland.
The owner is an unidentified collector.
Gehrig retired after being diagnosed with amyotrophic lateral sclerosis, now known as Lou Gehrig's disease. In his farewell speech that day, he said, "I consider myself the luckiest man on the face of the Earth."
Heritage's director of sports memorabilia, Chris Ivy, calls it "the most significant baseball ticket in the world."
Watch an excerpt of the speech:
[mlbvideo id="3380590" width="400" height="224" /]