It happened just after 10 a.m. on I-43 at Zander Road.
Police say a 23-year-old man driving a van crossed the median and crashed into the woods.
The man was in and out of consciousness when officers arrived. He was transported by Eagle III to a hospital with serious injuries.
I-43 northbound was closed for about 30 minutes after the crash.
Authorities say the cause of the accident is unknown at this time.