Appleton police say officers from three agencies saw the suspects buy and sell drugs at several locations in the city.
Police found 282 grams of crack cocaine worth about $42,300 and 73 grams of heroin worth about $14,600. Police also took money from several of the suspects as evidence.
Those arrested were a 24-year-old woman from Park City, Illinois; a 23-year-old man from Zion, Illinois; a 42-year-old man from Kimberly; a 53-year-old man from Kaukauna; and a 43-year-old woman from Menasha.
None of the five has been formally charged in the case.