Segura homered for a 4-1 lead in the second. Khris Davis added a solo shot for the Brewers, who have won five of six and are a big league-best 16-6.
Lohse (4-1) allowed five hits and no walks in seven innings. Brewers batters backed him with nine hits at Miller Park, where the team had been averaging just two runs and six hits entering the night.
Francisco Rodriguez pitched a scoreless ninth for his ninth save, his 313th over 12 full big league seasons.
Tyson Ross (2-3) allowed a season-high five earned runs in six innings.