The party announced Thursday that the first-term governor will give the speech at the annual gathering on May 3.
Other speakers include Wisconsin Gov. Scot Walker, U.S. Sen. Ron Johnson and U.S. Rep. Paul Ryan.
Pence says in a statement that he was excited to join with fellow Republicans to unite behind Walker, who is running for re-election this year. Pence says that unlike "the failed leadership in Washington, states are leading the way forward with real change and a renewed focus on the taxpayer, not on bigger government."
Mary Burke is Walker's anticipated Democratic opponent. She's a former Trek Bicycle Corp. executive and state commerce secretary.